# Clinical data for SEA-AD dorsolateral prefrontal cortex snRNAseq samples

**URL:** <https://community.brain-map.org/t/clinical-data-for-sea-ad-dorsolateral-prefrontal-cortex-snrnaseq-samples/2143>\
**Category:** Technical\
**Tags:** transcriptomics, atlas-human-brain-adult\
**Created:** [February 16, 2023, 6:55pm UTC](https://community.brain-map.org/t/clinical-data-for-sea-ad-dorsolateral-prefrontal-cortex-snrnaseq-samples/2143 "2023-02-16T18:55:21Z")\
**Posts on this page:** 3\
**Page:** 1

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**Author:** ![joseph-siefert](https://yyz1.discourse-cdn.com/flex027/user_avatar/community.brain-map.org/joseph-siefert/32/777_2.png) [@joseph-siefert](https://community.brain-map.org/u/joseph-siefert)\
**Post date:** [February 16, 2023, 6:55pm UTC](https://community.brain-map.org/t/clinical-data-for-sea-ad-dorsolateral-prefrontal-cortex-snrnaseq-samples/2143/1 "2023-02-16T18:55:21Z")

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Hello, I am wondering how to obtain the clinical data for the SEA-AD dorsolateral prefrontal cortex snRNAseq samples. Specifically, variables such as apoe genotype, amyloid, pmi, brrksc, ceradsc, cogdx, nft, plaq\_n, gpath, tangles.

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**Author:** ![eitan.kaplan](https://avatars.discourse-cdn.com/v4/letter/e/5f8ce5/32.png) [@eitan.kaplan](https://community.brain-map.org/u/eitan.kaplan)\
**Post date:** [March 1, 2023, 5:27pm UTC](https://community.brain-map.org/t/clinical-data-for-sea-ad-dorsolateral-prefrontal-cortex-snrnaseq-samples/2143/2 "2023-03-01T17:27:35Z")

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Hi, donor metadata for the SEA-AD cohort can be found on the SEA-AD documentation page here: [Seattle Alzheimer’s Disease Brain Cell Atlas - brain-map.org](https://portal.brain-map.org/explore/seattle-alzheimers-disease/seattle-alzheimers-disease-brain-cell-atlas-download)?

The “ **Donor metadata** ” file includes APOE4 yes/no (does this person carry an APOE4 allele), neuropathological scores such as Braak, Thal, CERAD, ADNC, and cognitive status (w/ or w/o dementia).

There is also quantitative neuropath data from Middle Temporal Gyrus (MTG) in the file “**Quantitative neuropathology summary data (MTG)**”  
That includes measurements of Abeta, pTau, pTDP43, a-synuclein, Neun+ cells, IBA1+ cells, and GFAP+ cells from quantitative analysis of stained neuropathology images from Middle Temporal Gyrus (MTG).

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**Author:** ![joseph-siefert](https://yyz1.discourse-cdn.com/flex027/user_avatar/community.brain-map.org/joseph-siefert/32/777_2.png) [@joseph-siefert](https://community.brain-map.org/u/joseph-siefert)\
**Post date:** [March 1, 2023, 8:35pm UTC](https://community.brain-map.org/t/clinical-data-for-sea-ad-dorsolateral-prefrontal-cortex-snrnaseq-samples/2143/3 "2023-03-01T20:35:10Z")

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Great, thanks!