# Neuromodulator-releasing subclasses UMAP from Yao et. al. 2023

**URL:** <https://community.brain-map.org/t/neuromodulator-releasing-subclasses-umap-from-yao-et-al-2023/3437>\
**Category:** Allen Brain Cell (ABC) Atlas\
**Tags:** atlas-cell-types\
**Created:** [July 1, 2024, 11:45pm UTC](https://community.brain-map.org/t/neuromodulator-releasing-subclasses-umap-from-yao-et-al-2023/3437 "2024-07-01T23:45:02Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![alwaysnow](https://yyz1.discourse-cdn.com/flex027/user_avatar/community.brain-map.org/alwaysnow/32/1932_2.png) [@alwaysnow](https://community.brain-map.org/u/alwaysnow)\
**Post date:** [July 1, 2024, 11:45pm UTC](https://community.brain-map.org/t/neuromodulator-releasing-subclasses-umap-from-yao-et-al-2023/3437/1 "2024-07-01T23:45:02Z")

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Hello,

I was wondering if the UMAP from figure 3 of [Yao et. al. 2023](https://www.nature.com/articles/s41586-023-06812-z) is planned for incorporation into the ABC Atlas. I noticed that most other UMAPs from the paper have been added, just curious if the modulatory-neurotransmitter-releasing one is soon to come. Also don’t seem to see the corresponding dataset in the [data collections](https://knowledge.brain-map.org/data/LVDBJAW8BI5YSS1QUBG/collections) page either, unless I am looking in the wrong place?

Cheers

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**Author:** ![rachel.hostetler](https://yyz1.discourse-cdn.com/flex027/user_avatar/community.brain-map.org/rachel.hostetler/32/1418_2.png) [@rachel.hostetler](https://community.brain-map.org/u/rachel.hostetler)\
**Post date:** [July 17, 2024, 11:25pm UTC](https://community.brain-map.org/t/neuromodulator-releasing-subclasses-umap-from-yao-et-al-2023/3437/2 "2024-07-17T23:25:59Z")

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Hello,

This might answer your question. I used the ABC atlas to filter the lefthand UMAP by the 31 subclasses featured in Fig 3a, and then filtered the righthand UMAP by neurotransmitters. In the ABC Atlas neurotransmitter filters, all serotonergic (sero, glut-sero, GABA-sero, and glut-GABA-sero) are grouped together under sero, same with noradrenergic, dopaminergic and cholinergic.

Click here to see the UMAPs:  
[https://knowledge.brain-map.org/abcatlas#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%2BAAAABAAACEc0STRHRkpYSkI5QVRaM1BUWDEACUxWREJKQVc4Qkk1WVNTMVFVQkcACgALAW5vbmUAAm5vbmUAAwEEAQACIzAwMDAwMAADyAEABQEBAiMwMDAwMDAAA8gBAAAAAUFQOEpOTjVMWUFCR1ZNR0tZMUIAAlExTkNXV1BHNkZaMEROSVhKQlEAAwQBRlMwMERYVjBUOVIxWDlGSjRRRQACAAABUVk1UzhLTU81SExKVUYwUDAwSwACHzA0NCBPQiBEb3BhLUdhYmEAMDU4IFBBTC1TVFIgR2FiYS1DaG9sADA2OSBMU1ggTmt4Mi0xIEdhYmEAMDg2IE1QTy1BRFAgTGh4OCBHYWJhADA4OSBQVlIgU2l4MyBTb3gzIEdhYmEAMDkxIEFSSC1QVmkgU2l4NiBEb3BhLUdhYmEAMDkyIFRNdi1QTXYgVGJ4MyBIaXN0LUdhYmEAMDk4IEFITi1TQlBWLVBWSGQgUGRybTEyIEdhYmEAMDk5IFNCUFYtUFZhIFNpeDYgU2F0YjIgR2FiYQAxMDEgWkkgUGF4NiBHYWJhADEwMiBETUgtTEhBIEdzeDEgR2FiYQAxMDYgUFZwby1WTVBPLU1QTiBIbXgyIEdhYmEAMTA3IERNSCBIbXgyIEdhYmEAMTM4IFBIIFBpdHgyIEdsdXQAMTQ1IE1IIFRhYzIgR2x1dAAxNTkgSUYtUkwtQ0xJLVBBRyBGb3hhMSBHbHV0ADE4MiBDVU4tUFBOIEV2eDIgTWVpczIgR2x1dAAxODMgUEJHIE10bnIxYSBHbHV0LUNob2wAMTg0IFBBRyBUY2YyNCBHbHV0ADIxNSBTTmMtVlRBLVJBbWIgRm94YTEgRG9wYQAyMTYgTUItTVkgVHBoMiBHbHV0LVNlcm8AMjE3IFBCIExteDFhIEdsdXQAMjIyIFBCIEV2eDIgR2x1dAAyNDIgUEdSTmQgRG1ieDEgR2x1dAAyNDMgUEdSTi1QQVJOLU1EUk4gSG94YjUgR2x1dAAyNDggTVYtU1BJViBaaWM0IE5ldXJvZDIgR2x1dAAyNTEgTlRTIERiaCBHbHV0ADI1MiBETVggVklJIFRieDIwIENob2wAMjYxIEhCIENhbGNiIENob2wAMjg1IE1ZIExoeDEgR2x5LUdhYmEAMzAxIE1WIE5yNGEyIEdseS1HYWJhAAABMTVCSzQ3RENJT0YxU0xMVVc5UAACAAABQ0JHQzBVMzBWVjlKUFI2MFRKVQACAAAEAQECgazlhIG8aWIDhJiXYoT%2BMccABQAGAQECNE1WN0hBNURHMlhKWjNVRDhHOQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D](https://knowledge.brain-map.org/abcatlas#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%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%2BMccABQAGAQECNE1WN0hBNURHMlhKWjNVRDhHOQADfgAAAAQAAAhHNEk0R0ZKWEpCOUFUWjNQVFgxAAlMVkRCSkFXOEJJNVlTUzFRVUJHAAoACwFub25lAAJub25lAAMBBAEAAiMwMDAwMDAAA8gBAAUBAQIjMDAwMDAwAAPIAQAAAAIDAA%3D%3D)