# X,Y,Z query for gene expression

**URL:** <https://community.brain-map.org/t/x-y-z-query-for-gene-expression/2615>\
**Category:** Technical\
**Tags:** allensdk\
**Created:** [October 4, 2023, 3:58pm UTC](https://community.brain-map.org/t/x-y-z-query-for-gene-expression/2615 "2023-10-04T15:58:25Z")\
**Posts on this page:** 2\
**Page:** 1

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**Author:** ![cvanleer](https://avatars.discourse-cdn.com/v4/letter/c/13edae/32.png) [@cvanleer](https://community.brain-map.org/u/cvanleer)\
**Post date:** [October 4, 2023, 3:58pm UTC](https://community.brain-map.org/t/x-y-z-query-for-gene-expression/2615/1 "2023-10-04T15:58:25Z")

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Hi everyone,

I am trying to build a pipeline in which it would be possible to extract the list of genes expressed in a specific set of x,y,z coordinates.

However, I am new to work with the Allen Brain API and have a bit of trouble to see how I can do such a query and on which dataset.

Thanks in advance for the answer.

Cheers,  
C

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<div class="post-metadata">

**Author:** ![lydian](https://yyz1.discourse-cdn.com/flex027/user_avatar/community.brain-map.org/lydian/32/174_2.png) [@lydian](https://community.brain-map.org/u/lydian)\
**Post date:** [October 26, 2023, 4:52pm UTC](https://community.brain-map.org/t/x-y-z-query-for-gene-expression/2615/2 "2023-10-26T16:52:38Z")

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One approach to doing this is the download expression grid for each ISH dataset. Since these grids are all aligned to a common reference, you can then look across all genes for your location / voxel of interest.

Take a look at  
[API - Allen Mouse Brain Atlas (brain-map.org)](http://help.brain-map.org/display/mousebrain/API)  
[Downloading 3-D Expression Grid Data - Allen Brain Atlas API (brain-map.org)](http://help.brain-map.org/display/api/Downloading+3-D+Expression+Grid+Data)