Cell types in middle temporal gyrus reference

PVM stands for “brain PeriVascular Macrophages”, and so the Microglia-PVM group essentially includes all immune cells.

In our SEA-AD MERFISH data, both cell types are relatively common, so I’m not sure why you aren’t seeing them. It could be the difference between cell-based and spot-based spatial transcriptomics methods, if the overall abundance (and therefore gene expression levels) of these types are low.

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