What would be the best RNAseq dataset that could be used as a control/to compare to the Ivy Glioblastoma dataset?
Hi @oliviabrito. Within the Ivy Glioblastoma Atlas Project, gene expression in “leading edge” can roughly be treated as a normal cortex. This can be seen by looking at the top differentially expressed genes between leading edge and the other regions, which are largely neuronal markers. At the time of publication, this was a unique RNA-seq data set; however, I think it is quite likely more recent RNA-seq datasets from other groups could use used as acontrol. Maybe @Ralph or others in the community could elaborate, if they have more recent information.