This latest data release significantly enhances the Genetic Tools Atlas by adding over 3,100 new in vivo mouse expression datasets. It includes characterization of several dozen transgenic mouse lines and more than 1,700 adeno-associated viruses (AAVs), representing over 1,000 cortical cell type enhancers and more than 400 basal ganglia (BG) cell type enhancers.
Scientists can now access an increased inventory of genetic tools with greater coverage across brain regions of interest. They can choose from expanded virus delivery methods, adding stereotaxic (STX) injections and transgenic mouse lines to the previously available retro-orbital (RO) and intracerebroventricular (ICV) injections.
Genetic Tools Atlas is part of the growing Brain Knowledge Platform and opens up endless possibilities for groundbreaking discoveries and breakthroughs in neuroscience. It enables neuroscientists to identify genetic tools to precisely target brain areas & identify the distribution of relevant cell types for their research. They are available to the research community via distribution partners:
- Find AAVs on addgene.org
- See transgenic lines at The Jackson Laboratory.
We’re planning to release additional experiments and image data in regular intervals. We value your feedback. Please let us know what you think and what you’d like to see in future updates!
Go to Genetic Tools Atlas
Learn more on portal.brain-map.org
Feature improvements
Access images in Neuroglancer directly from metadata table
Scientists can now skip the side info panel and go straight from the metadata table to an entry’s image in Neuroglancer. Click the links in the Image Series ID column to open the image in a new tab. This significantly reduces the number of clicks to image access.
File manifest download
Scientists can now download a file manifest for Genetic Tools Atlas. It enables access to the raw OME-Zarr images via their AWS OpenData file paths.
Note: For the most comprehensive data representation, we recommend downloading both the metadata and file manifest and joining the two tables on the Specimen ID column.
Side info panel - Images tab
The image preview now contains help text outlining it’s purpose and the preview image viewing controls (on hover). It will no longer show blank slides which previously caused confusion. Scientists can now preview the full slide for EPI images instead of individual sub-sections. A new button indicates a clearer path to Neuroglancer for more in-depth image viewing.
Neuroglancer image viewing
Neuroglancer color channel controls have been reconfigured to use invlerp controls. Scientists can use the added capabilities of these controls to customize image visualization to best suit their needs.
