ABC Anatomic Location Mapping Question

How To Allen Brain Cell (ABC) Atlas
1

Hello,

I am trying to understand the nomenclature that ABC uses for their regions of interests - specifically, I see that some use the Allen Brain Atlas nomenclature while some areas utilize the Modified Brodmann. I’m seeing if I am understanding this properly, and if so, if there are any “consolidated” atlas where it shows which nomenclatures were used. I’m trying to compare the spatial transcriptomic and cell lines with another brain map, and I’m not sure how I can map the two brain maps together if the nomenclatures are different. I can convert the other one to the ABC ontology for regions but also am not sure if there are MNI or spatial coordinates I can utilize for this…

Thank you for your help in advance.

2

Hello, thanks for your thoughtful question. The human anatomical atlas uses the Harmonized Ontology of Mammalian Brain Anatomy (HOMBA), which parcellates the cortex either using gyral features or Modified Brodmann. Both parcellation sets share the same subcortical structures. HOMBA is an update to the previous Allen Human Brain Reference Atlas described in Ding et al. 2016 JCN (PMID: 27418273).

We have recently released a whole brain human atlas that parcellates the MNI ICBM2009b template, see the reference page for links to download the data assets.