Comparing Gene Expression Between Healthy and ASAP PD Brain Regions

Hi,

ASAP-PMDBS cells were mapped to a healthy whole human brain (WHB) taxonomy (Siletti et al., 2023), which is hierarchical taxonomy of ~3.3 million cells (neurons and non-neuronal cells) with 31 superclusters, 461 clusters, and 3,313 subclusters spanning 105 anatomical dissections across the whole human brain. The 30 ASAP-PMDBS clusters were mapped at the WHB supercluster, cluster, and subcluster levels. Click on the hyperlinks to view the ASAP-PMDBS clusters in the Allen Brain Cell (ABC) Atlas side-by-side with the WHB neuronal and non-neuronal cells. Here you can also search for genes in the different datasets by clicking on the double helix on the lefthand panel.

If you have questions using the ABC Atlas, please check out the ABC Atlas User Guide.

Let me know if this is helpful or if you have further questions!