Hi Katherine,
We recognize the challenges in unpacking the large 10x matrices. Sufficient memory should help, but the script outlined here may also be of help: Gene expression matrix.cvs is too large to load it - #17 by jeremyinseattle
If you still have issues, feel free to share more specifics here and we can work it through with you.
In general: how big of a file/matrix is too big for you? (Conversely, what size is preferable?)
Tyler