GPi = EPN in mouse brain atlas?

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Hi everyone,

Just wanted to confirm that the GPi labelled on the adult mouse brain atlas is in fact the entopeduncular nucleus (EP/EPN)? I know they’re functional analogues and the literature shows histology in about the same place, but I just wanted to be certain, as I’m new to the field.

Thanks in advance!

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I reached out to Song-Lin Ding and he says: “The GPi in our mouse and human brain atlases are not the EP/EPN because in our human atlas (Ding et al., J comp Neurol, 2016), EP/EPN (see EnPN from pages 3254-3262) is a very small nucleus located medial to GPi. However, in mouse literature, some people treated GPi as EP/EPN.”

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Thanks for your response, Jeremy. I am a little confused though, as for a long time researchers were saying that there is no GPi in rodents at all (which is why they used EPN as a homolog), and only recently have they begun to discover the possibility that rodent GP/GPe may contain a GPi segment in a similar position to humans, the internal aspect of the structure. Could you clarify which stream of literature the rodent GPi in your atlas comes from?